Cardiovascular Disease
- PD risk factor for CVD http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2504402
- CHD pt risk of death increase with every tooth lost http://cpr.sagepub.com/content/early/2015/12/14/2047487315621978
- 80-90% Heart Disease can be prevented with lifestyle changes http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(04)17018-9/abstract
- PD treatment reduces hospital admissions and lowers medical costs (Stroke $5168/pt/yr; Heart Disease $1090/pt/yr) https://www.unitedconcordia.com/dental-insurance/dental/conditions/ucwellness-oral-health-study/results-ucwellness-oral-health-study/
- PD directly linked to arterial inflammation http://content.onlinejacc.org/article.aspx?articleid=1144173
- Subgingival periodontal directly linked to increase in BP (both diastolic and systolic) and also hypertension prevalence http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3403746/
- Dental Infection and Oral Bacteria may be associated with development of acute coronary thrombosis (heart attack) http://circ.ahajournals.org/content/127/11/1219
- Heart Disease is #1 cause of death in US – claiming more lives than all cancers combined http://www.cdc.gov/heartdisease/facts.htm
- Oral Bacteria can invade arterial wall (basement membrane) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084572/
Diabetes
- 29.1 million with diabetes in the US (the number is increasing rapidly – 26M in 2010), 1 in 4 don’t know they have it, More than 1 in 3 has pre-diabetes http://www.cdc.gov/features/diabetesfactsheet/
- 95% of people with diabetes also have periodontal disease. Diabetics with periodontal disease have more difficulty controlling their blood sugar level. 1 in 3 healthcare dollars is spent caring for people with diabetes. $332 Billion Per Year. Treating gum disease lowers annual cost associated with diabetes. ($2840/pt/yr; reduces 39.4%/yr Diabetes Hospital Admissions). https://www.adha.org/resources-docs/7228_Oral_Health_Total.pdf
- This paper greatly underpredicted the growth in diagnoses and spending http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2782981/
- PD Tx can improve glycemic control in pts with diabetes https://www.unitedconcordia.com/dental-insurance/dental-health/conditions/ucwellness-oral-health-study/results-ucwellness-oral-health-study/
Alzheimer’s
- Gum disease bacteria can be found in the brains of Alzheimer’s patients. Chronic Systemic Inflammation caused by PD increases the risk for AD. AD patients with gum disease have significantly more rapid cognitive decline than AD pts with healthy mouth. http://www.journaloforalmicrobiology.net/index.php/jom/article/view/29143
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4488989/
- Inflammation and progression of AD
29, 30. Inflammation and development of AD
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3887148/
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3253025/
Inflammation
- PD Tx results in reduction of systemic inflammation http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.328.8280&rep=rep1&type=pdf
- Oral Inflammation caused by pathogens induces a systemic increase in inflammatory markers http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0055265
Periodontal Disease
- Nearly half of American adults have periodontitis (the most severe form of periodontal disease) https://www.perio.org/consumer/cdc-study.htm
- 80% adults over 35 have some form of periodontal disease http://www.colgate.com/en/us/oc/oral-health/conditions/gum-disease/article/periodontal-disease
Pregnancy
14, 19, 20.Adverse Pregnancy Outcomes
http://jdh.adha.org/content/81/suppl_1/116.full.pdf
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3144105/
http://www.futuremedicine.com/doi/pdf/10.2217/whe.11.37
- 35 y/o healthy pregnant woman 39 weeks 5 days pregnant – stillbirth – Yiping Han says cause was F. nucleatum infection http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3004155/
- Mechanism of F. nucleatum in intrauterine infection https://cwru.pure.elsevier.com/en/projects/mechanism-of-f-nucleatum-in-intrauterine-infection-2
Colorectal Cancer
- Oral Bacteria in Colon Cancer https://cwru.pure.elsevier.com/en/projects/fusobacterium-nucleatum-mediated-stimulation-of-colorectal-cancer
Pancreatic Cancer
- Recent studies show that the presence of 2 oral pathogenic bacteria (Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans ) increases a person’s risk for pancreatic cancer by more than 50 percent (P.g. 59%; A.a. 119%). http://www.aacr.org/Newsroom/Pages/News-Release-Detail.aspx?ItemID=876#.V8MJIGVflNF
- having a healthy oral biofilm (your mouth has only the good bacteria) is protective against developing pancreatic cancer. http://www.colgate.com/en/us/oc/oral-health/conditions/cancer/article/ada-10-oral-bacteria-may-signal-risk-for-pancreatic-cancer
Lung, Kidney, Pancreatic, and White Blood Cell Cancer
- Gum disease significantly increases the risk risk factor for all of these cancers http://www.thelancet.com/journals/lanonc/article/PIIS1470-2045(08)70106-2/fulltext
Oral Cancer
- It is estimated that 60% of all cancers of the mouth are caused by HPV. http://www.cdc.gov/std/hpv/stdfact-hpvandoropharyngealcancer.htm
- The leading cause of oropharyngeal cancer is HPV http://oralcancerfoundation.org/hpv/
- Over 200 strains of HPV, 9 cause cancer (another 6 might also cause cancer). HPV16 (same as cause for cervical, anal, and penile cancers) is the main cause for oropharyngeal cancer http://oralcancerfoundation.org/hpv/hpv-oral-cancer-facts.php
- Chronic periodontitis significantly increases risk for tongue cancer http://archotol.jamanetwork.com/article.aspx?articleid=484728
Depression
- After controlling for known contributing factors (like body mass index and inflammatory marker hsCRP), researchers found that the incidence of depression was greater for those who suffered from more unhealthy dental conditions. Furthermore, researchers found that the more dental conditions subjects had, the greater severity of their depression. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4520114/
Artificial Joints and Valves
25, 26. Oral pathogens can enter the bloodstream and infect artificial joints https://www.drugwatch.com/knee-replacement/complications/
- Oral pathogens infect artificial valves http://my.clevelandclinic.org/services/heart/disorders/heart-valve-disease/endocarditis-protection
Oral Biofilm
- Oral bacteria can be transmitted by kissing http://microbiomejournal.biomedcentral.com/articles/10.1186/2049-2618-2-41
- 11 pathogens linked to oral and systemic disease https://www.sciencedaily.com/releases/2013/01/130103114130.htm